2024
39. D. Maity*, N. Sivakumar*, P. Kamat, N. Zamponi, C. Min, H. Jayatilaka, W. Du, A. Johnston, A. Agrawal, D. Riley, L. Venturutti, A.M. Melnick, L. Cerchietti, J. Walston, J.M. Phillipo; Profiling emergent behaviors of single-cell motility, 2024, Advanced Science, (to appear)
Preprint: https://www.biorxiv.org/content/10.1101/2022.09.21.508955v2
38. A. Cordova, B. Niese, P. Sweet, P. Kamat, J.M. Phillip, V. Gordon, L.M. Contreras, 2024, Applied and Environmental Microbiology
Preprint: https://www.biorxiv.org/content/10.1101/2024.01.17.576117v1
37. S.M. Engels, P. Kamat, G.S. Pafilis, Y. Li, A. Agrawal, D.J. Haller, J.M. Phillipo, L.M. Contreraso, Particulate matter composition drived differential molecular and morphological responses in lung epithelial cells, 2024, PNAS Nexus
Preprint: https://www.biorxiv.org/content/10.1101/2023.05.17.541204v1
2023
36. L.V. Cappelli*, D. Fiore*, J.M. Phillip*, L. Yoffe*, F. Di Giacomo*, W. Chiu, Y. Hu, C. Kayembe, M. Ginsberg, L. Consolino, J.G.B. Duran, N. Zamponi, A.M. Melnick, F. Boccalatte, W. Tam, O. Elemento, S. Chiaretti, A. Guarini, R. Foà, L. Cerchietti, S. Rafii, G. Inghirami, Endothelial cell-leukemia interactions remodel drug responses, uncovering T-ALL vulnerabilities, 2023, Blood
35. I. Aifuwa, B.C. Kim, P. Kamat, B. Starich, A. Agrawal, D. Tanrioven, T.R. Luperchio, A. Jimenez, T. Perestrelo, K. Reddy, T. Ha, D. Wirtz, J.M. Philip, Senescent stroma induce nuclear deformation in cancer cells via inhibition of RhoA/ROCK/myosin based cytoskeletal tension, 2023, PNAS Nexus
Preprint: https://www.biorxiv.org/content/10.1101/2021.11.17.468902v1
2022
34. J.M. Phillip*, A. Cheetham*, D. Stern*, R. Lin, Y. Li, Y. Wang, D. Rini, H.Cui, J.D. Walston, P.M. Abadir, Nature-inspired delivery of mitochondria-targeted angiotensin receptor blocker, 2022, PNAS Nexus
33. F. Cayrol, M. Debernardi, M.V. Revuelta, A. Paulazo, J.M Philip, N. Zamponi, H. Sterle, M. Celeste Díaz Flaqué, C.Magro, J. Ruan, L. Cerchietti, G. Cremaschi, Inhibition of the integrin alpha-V beta-3 reverts the paradoxical effect of levothyroxine replacement during bexarotene therapy in cutaneous T-cell lymphoma, 2022, Molecular Cancer Therapeutics
32. A. Sneider, J. H. Kim, A. Kiemen, P-H. Wu, M. Habibi, M. White, J.M. Phillip, L. Gu, D. Wirtz, Deep learning identification of stiffness markers in breast cancer, 2022, Biomaterials
Preprint: https://www.biorxiv.org/content/10.1101/2020.12.17.423077v1
31. M. Clauzure, M.A. Táquez Delgado, J.M. Phillip, M.V. Revuelta, L. Cerchietti, V.A. Medina; Histamine H4 Receptor Agonism Induces Anti-tumor Effects in Human T-Cell Lymphoma, 2022, International Journal of Molecular Sciences
2021
30. E. Gomez de Mariscal, A. Sneider, H. Jayatilaka, J.M. Phillip, D. Wirtz, A. Munoz-Barrutia; Use of the p‐values as a size dependent function to address practical differences when analyzing large datasets, 2021, Scientific Reports
Preprint: https://www.biorxiv.org/content/10.1101/2019.12.17.878405v4
29. M.N. Calvo-Vidal, N. Zamponi, J. Krumsiek, M.A. Stockslager, M.V. Revuelta, J.M. Phillip, R. Marullo, E. Tikhonova, N. Kotlov, J. Patel, S.N. Yang, L. Yang, T. Taldone, C. Thieblemont, J.P Leonard, P. Martin, G. Inghirami, G. Chiosis, S.R. Manalis, L. Cerchietti, Oncogenic HSP90 facilitates metabolic alterations in aggressive B-cell lymphomas, 2021, Cancer Research
Preprint: https://www.biorxiv.org/content/10.1101/2020.05.29.119925v1
28. N. Kotlov, A. Bagaev, M.V. Revuelta, J.M. Phillip, M.T. Cacciapuoti, Z. Antysheva, V. Svekolkin, E. Tikhonova, N. Miheecheva, N. Kuzkina, G. Nos, F. Tabbo, F. Frenkel, P. Ghione, R. Ataullakhanov, M. Tsiper, N. Almog, N. Fowler, A.M. Melnick, J.P. Leonard, G. Inghirami, L. Cerchietti, Clinical and biological subtypes of B-cell lymphoma revealed by microenvironmental signatures, 2021, Cancer Discovery
27. L. Fontan, R. Goldstein, G. Casalena, M. Durant, M.R. Teater, J. Wilson, J.M. Phillip, M. Xia, S. Shah, I. Us, H. Shinglot, A. Singh, G. Inghirami, A. Melnick, Identification of MALT1 feedback mechanisms enable rational design of potent anti-lymphoma regimens for ABC-DLBCL, 2021, Blood
26. J.M. Phillipo, N. Zamponi, M.P. Phillip, J. Daya, S. McGovern, W. Williams, H. Jayatilaka, P-H. Wu, J.D. Walston, D. Wirtz, Fractional distribution among motility states during ageing, 2021, Communications Biology
Preprint: https://www.biorxiv.org/content/10.1101/2020.04.29.069286v1
25. J.M. Phillip*, Kyu Sang Han*, W.C. Chen, D. Wirtz, P-H. Wu, A robust unsupervised machine learning method to quantify morphological heterogeneity of cells and nuclei, 2021, Nature Protocols
2020
24. N. Yusufova, A. Soshnev, A. Kloetgen, M. Teater, A. Osunsade , J. Camarillo , C.R. Chin, A. Doane, B.J. Venters, S. Portillo-Ledesma, J. Conway, J.M. Phillip, O. Elemento , D. Scott , W. Beguelin , J.D. Licht , N. Kelleher , L. Staudt , A. Skoultchi, M-C. Keogh, E. Apostolou , C. Mason, M. Imielinski , T. Schlick, Y. David , A. Tsirigos , D. Allis, E. Cesarman, A.M. Melnick, Histone 1 deficiency drives lymphoma through disruption of 3D chromatin architecture, 2020, Nature
23. L. Venturutti, M. Teater, A. Zhai, A. Chadburn, L. Babiker, D. Kim, W. Beguelin, T.C. Lee, Y. Kim, C.R. Chin, W.T. Yewdell, B. Raught, J.M. Phillip, Y. Jiang, L.M. Staudt, M.R. Green, J. Chaudhuri, O. Elemento, P. Farinha, A.P. Weng, M.D. Nissen, C. Steidl, R.D. Morin, D.W. Scott, G.G. Prive, A.M. Melnick, TBL1XR1 Mutations Drive Extranodal Lymphoma by Inducing a Pro-tumorigenic Memory Fate, 2020, Cell
22. D. Fiore, L.V. Cappelli, P. Zumbo, J.M. Phillip, Z. Liu, S. Cheng, L. Yoffe, P. Ghione, F. Di Maggio, A. Dogan, I. Khodos, E. de Stanchina, J. Casano, W. Tam, D. Betel, L. Cerchietti, R. Rabadan, S. Horowitz, D. Weinstock, G. Inghirami, A novel JAK1 mutant Breast Implant Associated – Anaplastic Large Cell Lymphoma Patient Derived Xenograft to foster preclinical discoveries, 2020, Cancers
21. W. Béguelin, M. Teater, C. Meydan, K.B. Hoehn, J.M. Phillip, A.A. Soshnev, L. Venturutti, M.T. Calvo-Fernández, H. Shen, J.M. Camarillo, N.L. Kelleher, C.E. Mason, O. Elemento, C.D Allis, S.H. Kleinstein, A.M. Melnick, EZH2 gain of function mutations epigenetically reprograms the humoral immune response to yield a pre-malignant lymphoma niche, 2020, Cancer Cell
20. T. Dalton, E. Doubrovina, D. Pankov, R. Reynolds, A. Selvakumar, T. Vizconde, B. Savalia, V. Dyomin, H. Scholze, C. Weigel, C. Oakes, A. Alonso, O. Elemento, H. Pan, J.M. Phillip, R. O’Reilly, B. Gewurz, E. Cesarman, L. Giulino-Roth; Epigenetic reprogramming sensitizes immunologically silent EBV+ lymphomas to viral directed immunotherapy, 2020, Blood
19. P-H. Wu, D. Gilkes, J.M. Phillip, A. Narkar, T. Cheng, J. Marchand, M-H. Lee, R. Li, D. Wirtz, Single-cell Morphology encodes metastatic potential, 2020, Science Advances
2019
18. T.M. Fernando*, R. Marullo*, B. Pera, J.M. Phillip, S.N. Yang, G. Lundell-Smith, I. Torregroza, H. Ahn, T. Evans, G.G. Privé, M. Hirano, A.M. Melnick, L. Cerchietti, BCL6 evolved to enable stress tolerance in vertebrates and is broadly required by cancer cells to adapt to stress, 2019, Cancer Discovery
17. H. Jayatilaka, J.M. Phillip, Slowing the spread of cancer: preventing cell communication to stop metastasis, 2019, Future Medicine
2018
16. J.M. Phillip, N. Zamponi, M.P. Phillip, It’s a numbers game—Density dependent MMP activity mediates cell migration, 2018, Oncotarget
15. Y. Yu, Y.S. Rahmanto, M-H. Lee, P-H. Wu, J.M. Phillip, C-H. Huang, M.I. Vitolo, S. Gaillard, S.S. Martin, D.Wirtz, T-L. Wang, I-M. Shih, Activity of Spleen Tyrosine Kinase regulates motility and invasion through modulating actin dynamics in cancer cells, 2018, Oncogene
14. X. Wei*, M.N. Calvo-Vidal*, S. Chen, G. Wu, M.V. Revuelta, J. Sun, J. Zhang, M.F. Walsh, K.E. Nichols, V. Joseph, C. Snyder, C.M. Vachon, J.D. McKay, S.P. Wang, D.S. Jayabalan, L.M Jacobs, D. Becirovic, R.G. Waller, M. Artomov, A. Viale, J. Patel, J.M.Phillip, S. Chen-Kiang, K. Curtin, M. Salama, D. Atanackovic, R. Niesvizky, O. Landgren, S.L. Slager, L.A. Godley, J. Churpek, J.E. Garber, K.C. Anderson, M.J. Daly, R.G. Roeder, C. Dumontet, H.T. Lynch, C.G. Mullighan, N.J. Camp, K. Offit, R.J. Klein, H. Yu, L. Cerchietti, S.M. Lipkin, Germline KDM1A Mutations Confer Susceptibility to Multiple Myeloma, 2018, Cancer Research
13. B. Pera, J. Krumsiek, R. Marullo, S.E. Assouline, J. Patel, J.M. Phillip, L. Roman-Gonzalez, K.K. Mann, L. Cerchietti, Panobinostat alters B-cell lymphoma metabolism resulting in increased dependency on PI3K activity through the choline pathway, 2018, eBioMedicine
2017
12. H. Jayatilaka, A. Giri, M. Karl, I. Aifuwa, N. Trenton, J.M. Phillip, S. Khatau, D. Wirtz, EB1and cytoplasmic dynein mediate protrusion dynamics for efficient three-dimensional cell migration, 2017, FASEB
11. J.M. Phillip, P-H. Wu, D. Gilkes, W. Williams, S. McGovern, J. Daya, J. Chen, I. Aifuwa, J.S.H. Lee, R. Fang, J. Walston, D. Wirtz, Biophysical and biomolecular determination of cellular age in humans, 2017, Nature Biomedical Engineering
10. F. Cayrol, P. Praditsuktavorn, T.M. Fernando, N. Kwiatkowski, R. Marullo, M.N. Calvo-Vidal, J.M. Phillip, B. Pera, S.N. Yang, K. Takpradit, L. Roman, M. Gaudiano, R. Crescenzo, J. Ruan, G. Inghirami, T. Zhang, G. Cremaschi, N.S. Gray, L. Cerchietti, THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors, 2017, Nature Communications
2016
9. K.M. Stroka, B.S. Wong, M. Shriver, J.M. Phillip, D. Wirtz, A. Kontrogianni, K. Konstantopoulos, Loss of giant obscurins from breast epithelium alters cell mechanobiology and mechanosensitivity, 2016, Oncotarget
8. M.Y. Shah*, E. Martinez-Garcia*, J.M. Phillip, A.B. Chambliss, R. Popovic, T. Ezponda, E.C. Small, C. Will, M.P. Phillip, P. Neri, N.J. Bahlis, D. Wirtz, J.D. Licht, MMSET/WHSC1 enhances DNA damage repair leading to an increase in resistance to chemotherapeutic agents, 2016, Oncogene
2015
7. P-H. Wu*, J.M. Phillip*, S.B. Khatau, W-C. Chen, J. Stirman, S. Roseel, K. Tschudi, J. Van-Patten, M. Wong, S. Gupta, A.S. Baras, A. Maitra, D. Wirtz, Evolution of cellular morpho-phenotypes in cancer metastasis, 2015 Scientific Reports
6. J.M. Phillip*, I. Aifuwa*, J. Walston, D. Wirtz, The Mechanobiology of Aging, 2015, Annual Review of Biomedical Engineering
5. D-H. Kim, B. Li, F. Si, J.M. Phillip, D. Wirtz, S.X. Sun, Volume regulation and shape bifurcation in the cell nucleus, 2015, Journal of Cell Science
4. Y. Yu*, S. Gaillard*, J.M. Phillip, A. Pandey, T-C. Huang, S.M. Pinto, D. Wirtz, T-L. Wang, I-M. Shih, Inhibition of Spleen Tyrosine Kinase potentiates paclitaxel-induced cytotoxicity in ovarian cancer cells through stabilizing microtubules, 2015, Cancer Cell
2013
3. K.M. Aw Yong, Y. Zeng, D. Vindivich, J.M. Phillip, P-H. Wu, D. Wirtz, and R.H. Getzenberg, Morphological effects on expression of growth differentiation factor 15 (GDF15), a marker of metastasis ,2013, Journal of Cell Physiology
2. Q. Guo, J.M. Phillip, S. Majumdar, P-H. Wu, J. Chen, X. Calderon-Colon, O. Schein, B.J. Smith, M.M. Trexler, D. Wirtz, J. Elisseeff, Modulation of keratocyte phenotype by collagen fibril nanoarchitecture in membranes for corneal repair, 2013, Biomaterials
1. W.C. Chen*, P-H. Wu*, J.M. Phillip, S.B. Khatau, J.M. Choi, M.R. Dallas, K. Konstantopoulos, S.X. Sun, J.S. Lee, D. Hodzic, D. Wirtz, Functional interplay between the cell cycle and cell phenotypes, 2013, Integrative Biology
Patents
1. System and device for characterizing cells, U.S. Patent 8,934,698, issued January 13, 2015.
